Spam complaints are reports made by email recipients against emails they don't want in their inbox. It's important to understand how spam complaints work, and how to do your best to avoid them, because even legitimate senders get complaints.
An email that receives an excessive number of complaints, could result in your next email being blocked by ISPs, so that even people who do want to hear from you may not.
Industry standard for spam complaints is less than 0.02%. That's about one complaint for every 5,000 recipients.
How spam complaints are made
Most mailbox providers, also known as ISPs, include a prominent "This is Spam" button in the inbox to allow people to report unwanted emails. Here's an example "spam" button in an AOL account:

People click the spam (or junk) buttons for various reasons. It may be that they're confused about who you are, or why you're emailing them, or it could be because they can't find the unsubscribe link.
What happens when we receive complaints
As an email service provider (ESP), we have what is called a "feedback loop" with all of the major ISPs, for example: Yahoo, Outlook.com, Comcast. When a recipient marks an email as spam, their ISP notifies us through the feedback loop.
Complaints are recorded in your sent email report. The percentage displayed in reports is calculated based on the number of complaints made in comparison to the total number of emails sent.

Recipients who report your email as spam are immediately unsubscribed from your list, meaning you will no longer be able to send emails to that individual. Their email address is also added to your suppression list.
Every complaint received is recorded in our system, and we regularly calculate the percentage of complaints generated by each email.
Higher-than-normal complaints
If you send an email that receives more than a 0.2% complaint rate, we will notify you with a warning email that includes advice to help you address the situation.
We understand that even legitimate senders get complaints so, provided you're doing the right thing, do not be alarmed if you get a warning email from us.
Tips for preventing complaints
The best ways to avoid your emails being marked as spam are: